A Review of the AZD5847 Patent Landscape: A Scoping Report. Amin T. (2014)

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AZD5847 belongs to the oxazolidinone class of compounds, which function as protein synthesis inhibitors and were first discovered in the mid- 1980s. Linezolid was the first compound of the oxazolidinone class to be approved for marketing and is most commonly used to treat drug-resistant TB. However, the use of linezolid has been limited by toxicity concerns, particularly haematological effects after periods of treatment over 14 days.

AZD5847 (previously referred to as AZD2563, generic name posizolid) is a modified analogue of the linezolid compound. AZD5847 was originally designed for treatment of gram-positive infections but was subsequently repurposed as an anti-TB agent. Like linezolid, AZD5847 has a bactericidal effect against mycobacterium TB in macrophages as well as in murine models of acute and chronic TB infection.


Keywords: HIV, TB, treatment, drugs

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