Guidelines for Intensified Tuberculosis Case Finding and Isoniazid Preventive Therapy for People Living with HIV in Resource Constrained Settings

HIV is the strongest risk factor for developing tuberculosis (TB) disease in those with latent or new Mycobacterium tuberculosis infection. The risk of developing TB is between 20 and 37 times greater in people living with HIV than among those who do not have HIV infection. TB is responsible for more than a quarter of deaths in people living with HIV.

On 25–27 January 2010, WHO conducted a global policy meeting to review the evidence regarding ICF and IPT, and to reconceptualize the 1998 WHO/Joint United Nations Programme on HIV/AIDS (UNAIDS) Policy on TB prevention. Key questions were identified and a comprehensive review of the available scientific evidence was conducted to formulate the recommendations.

The final recommendations take into consideration the quality of evidence, cost, feasibility, and values and preferences of the community and health-care workers.