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Prevention of Mother-to-Child Transmission
Technical update_on_treatment_optimization_PMTCT

Clinical trials on PrEP began in 2005. These trials have focused on the effectiveness of PrEP among people who inject drugs, HIV serodiscordant couples, heterosexual men and women, women at higher risk of HIV exposure, and men and transgender women who have sex with men (MSM-TG). Of these, two have completed as planned, one was stopped early for effectiveness, and two others were stopped or had arms discontinued for reasons of futility.

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Together, We Can: The Success of the Mingende Practice Model for Preventing Parent-to-Child Transmission of HIV in Papua New Guinea. UNICEF (2011)The report documents the Mingende practice model for preventing parent-to-child transmission of HIV (PPTCT) and analyses factors leading to the success of the PPTCT programme at the Mingenede Rural Hospital (MRH), Papua New Guinea. It captures innovative methods and processes that have led to the MRH's successful follow up for the continuum of care to reduce fall out rates and improve timely ART provision as well as adherence.

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Global Plan_Elimination_HIV_Children

We believe by 2015, children everywhere can be born free of HIV and their mothers remain alive. The goal of the Global Plan is to move towards eliminating new HIV infections among children and keeping their mothers alive. This plan focuses on reaching
pregnant women living with HIV and their children—from the time of pregnancy until the mother stops breastfeeding. Prior to
pregnancy, and after breastfeeding ends, HIV prevention and treatment needs of mothers and children will be met within the existing continuum of comprehensive programmes to provide HIV prevention, treatment, care and support for all who need it.


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PMTCT Strategic Vision 2010–2015: Preventing Mother-to-Child Transmission of HIV to Reach the UNGASS and Millennium Development Goals. WHO (2010)An estimated 430 000 children were newly infected with HIV in 2008, over 90% of them through mother-to-child transmission (MTCT). Without treatment, about half of these infected children will die before their second birthday. Without intervention, the risk of MTCT ranges from 20% to 45%. With specific interventions in non-breastfeeding populations, the risk of MTCT can be reduced to less than 2%, and to 5% or less in breastfeeding populations.

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Prevention of Mother-to-Child Transmission of HIV: Expert Panel Report and Recommendations to the U.S. Congress and U.S. Global AIDS Coordinator. Lantos T and Hyde HJ (2010)

The independent Expert Panel issuing this report was established by Section 309 of the Tom Lantos and Henry J. Hyde United States Global Leadership Against HIV/AIDS, Tuberculosis, and Malaria Reauthorization Act of 2008 (“the Act”), P.L. 110-293. The Panel was also established in accordance with the provisions of the Federal Advisory Committee Act (FACA), as amended, codified in 5 U.S.C. App.

Source: Lantos T, & Hyde H. (2010). Prevention of Mother-to-Child Transmission of HIV: Expert Panel Report and Recommendations to the U.S. Congress and U.S. Global AIDS Coordinator: United States Global Leadership Against HIV/AIDS, Tuberculosis, and Malaria Reauthorization Act of 2008.



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Factsheet N°5: Prevention for Mother‐to‐Child Transmission (PMTCT) Services in Nepal. National Centre for AIDS and STD Control Teku, Kathmandu (2009)PMTCT in Nepal - Comprehensive PMTCT service started in Nepal from February 2005. - Government provides free ARV drugs and follow‐up testing for the baby free of cost from 18 months. - There are 17 PMTCT sites, of which 16 sites offer Pediatric ART and 5 sites provide CD4 testing onsite.

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The Fiji, Vanuatu, Kiribati and Solomon Islands Prevention of Mother-to-Child Transmission of HIV (PMTCT) Training Package. UNICEF (2008)Background on Prevention of Mother-to-child Transmission of HIV (PMTCT) Programmes
Of the 33.2 million people living with HIV worldwide at the end of 2007, 2.5 million were children under the age of 15 years. In 2007 alone, 420,000 children were newly infected with HIV—about 1,150 new infections in children each day. The most frequent source of HIV infection in infants and children is transmission from mother-to-child during pregnancy, labour and delivery, or breastfeeding. Comprehensive programmes for prevention of mother- to-child transmission of HIV (PMTCT)—including ARV therapy and prophylaxis—can significantly reduce the number of infants who are HIV-infected and promote better health for their mothers and families.

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Guidance on Global Scale-Up of the Prevention of Mother-to-Child Transmission of HIV. WHO and UNICEF (2007)AIDS has become a leading cause of illness and death among women of reproductive age in countries with a high burden of HIV infection. Infants born to women living with HIV can become infected during pregnancy, labour and delivery or postpartum through breastfeeding. More than 1400 children under 15 years of age therefore become infected with HIV every day, most through mother-to-child transmission. Children account for more than 10% of all new HIV infections.

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A National Assessment for Preventing HIV in Mother and Children: An Indonesian Story. Laksmono LH and Setyahadi MI (2006)By 2007, we are working towards the implementation of the integrated PMTCT. On the process of the implementation, we based our recent PMTCT programmes on the 3 by 5 policy.

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