Focus on Happy, Healthy Babies. The Global Fund. (2015)

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All babies have the right to a healthy start in life.

 

Every year, approximately 1.5 million HIV-positive women give birth. If they are unable to access medicine and services, they run the risk of transmitting HIV to their babies during pregnancy, delivery and the breastfeeding period.

Now, with only one pill a day started during pregnancy, along with delivery in a medical facility by a skilled health professional and continued treatment through the breastfeeding period, advances in antenatal care mean that the risk of HIV transmission from mother to baby can be virtually eliminated.


Keywords: HIV, PMTCT, breastfeeding, children, treatment

 

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Transmitted HIV Drug Resistance Survey in Two Provinces in Papua New Guinea. Lavu E, Dala N, Gurung A, et al. (2015)

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Surveillance of transmitted HIV drug resistance (TDR) in individuals recently infected with HIV was performed following WHO-suggested methods. The prevalence of transmitted HIV drug resistance (TDR) in recently infected antiretroviral drug naïve individuals in PNG has not been fully characterised.


Keywords: HIV, ART, PNG, prevalence, drug resistance

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Overview of regional implementation of the Political Declaration on HIV/AIDS and the Millennium Development Goals and Efforts to Ensure Universal Access in Asia and the Pacific. ESCAP. (2015)

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The present document aims to review the progress of the HIV response in the Asia-Pacific region, with a view to identifying the opportunities for further action afforded by the 2011 Political Declaration. In doing so, it also draws on the expressed commitments undertaken by ESCAP member States to address the HIV epidemic, including those reflected in resolutions 66/10, Regional call for action to achieve universal access to HIV prevention, treatment, care and support in Asia and the Pacific (19 May 2010) and 67/9, Asia-Pacific regional review of the progress achieved in realizing the Declaration of Commitment on HIV/AIDS and the Political Declaration on HIV/AIDS (25 May 2011).

 

Keywords: IGM, 2015, HIV, prevalence, treatment, care, prevention, gender, violence, ART, children, women

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An Ambitious Treatment Target to Help End the AIDS Epidemic. UNAIDS. (2014)

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HIV treatment is a unique tool in the AIDS response, preventing illness and death, averting new infections and saving money. As hopes for ending the AIDS epidemic depend  in large measure on the world’s ability to provide HIV treatment to all who need it, in a rights-based approach, final targets for universal treatment access are critical.

 

Keywords: HIV, coverage, testing, antiretroviral therapy (ART), antiretroviral drugs (ARV), key populations, 90-90-90

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A Review of the Delamanid Patent Landscape: A Scoping Report. Amin T. (2014)

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Delamanid was discovered via a screening programme carried out by Otsuka. The compound belongs to the nitroimidazole class of compounds and is a derivative of compound CGI-17341 whose anti-TB activity was already reported in 1993.4 Indeed, various 5- and 2-nitroimidazoles and 5-nitrofurans were already known to be effective against a variety of protozoan and bacterial infections in humans and animals. For example, the published international patent application WO 97/01562 previously disclosed a 6-nitro- 1,2,3,4-tetrahydro[2,1-b]-imidazopyran compound with bactericidal action in vitro to mycobacterium TB.

 

Keywords: HIV, TB, pediatric, testing, drugs, treatment

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Enhancing the Benefits of Antiretroviral Therapy in Vietnam: Towards Ending AIDS. Kato M, Long NH, Duong BD, et al. (2014)

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Vietnam has a concentrated HIV epidemic, with the highest HIV prevalence being observed among people who inject drugs (PWID). Based on its experience scaling-up robust HIV interventions, Vietnam aims to further strengthen its response by harnessing the preventive benefits of antiretroviral therapy (ART). Mathematical modelling suggests that prioritizing key populations for earlier access to ART, combined with other prevention interventions, may have significant impact on the epidemic, cost-effectively reducing new HIV infections and deaths. Pilot studies are being conducted to assess feasibility and acceptability of expansion of HIV testing and counselling (HTC) and early ART among key populations and to demonstrate innovative service delivery models to address challenges in uptake of services across the care cascade. Earlier access of key populations to combination prevention interventions, combined with sustained political commitment and supportive environment for key populations, are essential for maximum impact of ART on the HIV epidemic in Vietnam. 

 

Keywords: Antiretroviral therapy, HIV prevention, Concentrated epidemic, Vietnam, People who inject drugs 

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Policy Brief: Consolidated Guidelines on HIV Prevention, Diagnosis, Treatment and Care for Key Populations. WHO (2014)

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This policy brief provides an overview of key findings, data and figures of the new consolidated guidelines on HIV prevention, diagnosis, treatment and care for key populations. In addition, it offers an overview of the comprehensive package on interventions and a table summarizing WHO recommendations concerning key populations.

 

Keywords: HIV, men who have sex with men (MSM), people who inject drugs (PWID), sex workers, transgender, testing, treatment

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A Review of the PA-824 Patent Landscape: A Scoping Report. Amin T. (2014)

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Like delamanid, PA-824 belongs to the nitroimidazoles class of compounds and is a derivative of compound CGI-17341 whose anti-TB activity was reported as early as 1993.3 PA-824 was discovered by Patho- Genesis Corporation, which was subsequently acquired by Chiron Corporation. Novartis AG acquired Chiron Corporation in 2006.

PA-824 is a pro-drug, which requires reductive activation of an aromatic nitro group before it becomes effective against TB bacteria.4 Pre-clinical studies have demonstrated that PA-824 has potent bactericidal and sterilizing effects against DS-TB and MDR-TB. PA-824 has also been shown to be active against latent TB bacteria.

 

Keywords: TB, bacteria, orphan, drug, access

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Patents and Licences on Antiretrovirals: A Snapshot. Burrone E and Timmermans K. (2014)

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The report provides an overview of the patent landscape with respect to a select number of antiretroviral (ARV) medicines in developing countries as of April 2014. The focus is primarily on those ARVs that are recommended by the World Health Organization (WHO) as well as new ARVs that have either recently obtained regulatory approval or are in phase III clinical trials.

Part 1 provides a brief introduction to patents and licences and their effect on the market for ARVs. It introduces key concepts that will facilitate an understanding of the report. It also explains which data sources were used for the report and notes a number of disclaimers with regard to the information contained in the report. Part 2 is the core of the report. It outlines the patent status and licensing status of each ARV in the 81 developing countries for which data are available. For each ARV the report indicates whether that ARV is included in fixed-dose combinations for which there may be patents. General conclusions are drawn in light of the data. The key purpose is to provide an overview of the patent landscape for each ARV and, in particular, to show in which countries market competition for a given ARV is possible in view of existing patents and licences.

 

Keywords: HIV, treatment, medicines, ART, ARV

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Specifications and Quantities for Efficient Procurement of Essential Equipment and Laboratory Commodities for HIV. WHO. (2014)

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WHO, with support from Centers for Disease Control and Prevention (CDC), developed the present tool on specifications and quantities for efficient procurement of essential equipment and laboratory commodities for HIV.

The ultimate purpose of the tool is to facilitate the efficient procurement of laboratory equipment and laboratory commodities required to:

   - perform HIV diagnostic tests in adults, adolescent and children;
   - monitor treatment outcomes in patients on antiretroviral therapy.

Keywords: HIV infections, diagnosis, anti-retroviral agents, treatment outcome, technology medical

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http://aidsdatahub.org/sites/default/files/highlight-reference/document/WHO_Integrating_collaborative_TB_and_HIV_services_within_a_comprehensive_package_of_care_for_PWID_2016.pdf
http://aidsdatahub.org/sites/default/files/highlight-reference/document/India_IBBS_report_2014-15.pdf
http://aidsdatahub.org/sites/default/files/highlight-reference/document/India_HSS_report_2014-15.pdf
http://aidsdatahub.org/sites/default/files/highlight-reference/document/The_negative_impact_of_drug_control_on_public_health_2015.pdf
http://aidsdatahub.org/sites/default/files/highlight-reference/document/2015_young_people_drugs_en.pdf
http://aidsdatahub.org/sites/default/files/highlight-reference/document/Death_Penalty_for_Drug_Offences_Global_Overview_2015.pdf
http://aidsdatahub.org/sites/default/files/highlight-reference/document/Transforming_our_world_2015_UN.pdf
http://aidsdatahub.org/sites/default/files/highlight-reference/document/WHO_Consolidated_on_the_use_of_antiretroviral_drugs_for_treating_and_preventing_HIV_infection_2016.pdf
http://aidsdatahub.org/sites/default/files/highlight-reference/document/Consolidated_Strategic_Information_Guidelines_for_HIV_in_Health_Sector_2015.pdf
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